Zooming in on the real global risks:

1. custom-engineered prions/virions?
2. genetically engineered viruses
3. genetically engineered bacteria
4. cybernetic (combinations of bio and nano) microbes
5. molecular manufacturing - self-replicating nanites
6. molecular manufacturing - nanowarfare, arms races
7. human or near-human-level artificial intelligence - controlled self-improvement
8. human or near-human-level artificial intelligence - unrestrained self-improvement
9. human intelligence enhancement gone awry

Broadly, I categorize these risks as either self-replicating (1-6) or self-amplifying (7-9).

In terms of the time window of risk:

For 1-3, the risk window is approximately 2010 onward.
For 4, the risk window begins around 2010, but doesn’t get serious until 2020+.
For 5-6, this is a big unknown. Some argue for emerging risk as early as 2010, but 2020 onward seems more realistic to me. Once it emerges, it will balloon quickly.
The time frames for 7-9 are the most unsure and contentious. For those who see human-equivalent AI or human intelligence enhancement as prospects at all, predictions cluster around 2020-2030.

What do all these risks have in common? They’re relatively close, quite serious, and virtually ignored. There are only a handful of organizations that have looked at them in any detail.

Given all the resources devoted to improving quality of life, fighting disease, maintaining economic momentum, promoting democracy worldwide, and so on, it’s shocking that humanity has devoted so few resources to ensuring its own survival.

Are all of these risks so low in probability from the viewpoint of casual thinkers that they aren’t even worth talking about? I find this hard to believe. There are several prominent figures who have mentioned the risks: Stephen Hawking, Martin Rees, and Warren Buffett. There was recently a talk at the high-profile TED conference about global risk.

A confounding point is that many of the mentioned risks are based on technologies which may not exist yet. But genetically engineered viruses, for instance, do already exist. Even entirely synthetic viruses have been created. Cybernetic microbes do not yet exist, but are very close to being reality, perhaps 3-5 years in the future.

Molecular manufacturing (MM), AI, and human intelligence enhancement-based risks are more difficult to communicate. In the case of molecular manufacturing, the basic concepts still aren’t clear in the minds of many. Discussions of the technical requirements of molecular manufacturing (reliable mechanosynthesis and self-replicating robotics) do not tend to be especially controversial, but when the products (likely to be made of diamond) are mentioned, the controversy and incredulity meter often goes through the roof. More discussion and study is needed.

AI and human intelligence enhancement are the most contentious risks. A small group of people take the risks very seriously, another small group of people seem to believe that greater intelligence equals greater morality, so we have nothing to fear, and the largest group, including many self-described geeks, let Hollywood do the thinking for them. Another distraction here is spiraling off into philosophical debates and identity crises caused by exposure to the possibility that humans won’t be the most intelligent species on the planet forever.

Whichever risk you take most seriously yourself, even if none, my advice would be to keep an open mind about the possibilities. Many of these technologies aren’t even on the drawing board yet, though some are, and there is no such thing as an expert in many of these areas. As we figure out more, our probability estimates will surely change. My estimates of the time frame and intensity of the risks has changed numerous times in the five or so years that I’ve been reading books and papers about them.

If you consider study of the risks to be important, please join the Lifeboat Foundation, which seeks to fund full-time investigation into these issues.

Further resources:

Lifeboat Foundation Reports
“Existential Risks” by Nick Bostrom
“Immortalist Utilitarianism” by myself
“Risks” category on Accelerating Future
“Existential Risk Analysis” category on the People Database Blog
Singularity Institute for AI, looking into AI-related risks
Center for Responsible Nanotechnology, looking into nanotech-related risks