Improving Skull Protection via Biocompatible Implants Saturday, May 2 2009
cybernetics 11:26 am

A fundamental design flaw in the current human organism is a lack of sufficient protection for our most crucial organs, the cradles of intelligence and personality — the brain and spinal cord. Thanks to improvements in workplace safety, enforcement of drunk driving laws, and buckle-up campaigns, death due to injuries of the head and spinal cord have decreased throughout the last few decades, but many of us can name friends or family who were killed or permanently disabled by a traumatic head injury. The 5th leading cause of death, unintentional injuries, often involves fatal injuries to the head or spinal cord.
As the recent death of the actress Natasha Richardson demonstrates, “minor” head injuries can be fatal too.
According to the Franklin Institute:
Every 15 seconds, someone in the United States suffers a traumatic brain injury. Of the 1,000,000 people treated in hospital emergency rooms each year, 50,000 die and 80,000 become permanently disabled because of traumatic brain injury (TBI). This is higher than the combined incidence of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis.
Brain injuries occur more frequently than breast cancer or AIDS. One out of every fifty Americans is currently living with disabilities from TBI. There’s even an association between head injury and Alzheimer’s disease later in life.
Therefore, a call to develop implants to protect the brain and spinal cord from injury seems justified, even if the present technology is not perfect. Our present protection, which consists primarily of calcium hydroxylapatite, is just 6.5 mm thick in men (on average) and 7.1 mm thick in women. While it has some flexibility due to embedded collagen, the skull is essentially brittle, which, while enhancing its strength, makes it susceptible to catastrophic failure in an accident. If our skulls were just slightly thicker or stronger, how many lives would be saved? No one knows.
The most obvious proposal would be to try to find out some way (even if it takes decades) to replace the skull with a fullerene composite, which would be lightweight, over 100 times stronger than bone, and could probably be made biocompatible. What is the current state of the art in the field?
Hydroxylapatite ceramic skull plates have already been used by brain surgeons to patch holes in the brain caused by traumatic injury. These can be precisely shaped to fit the hole in the skull. These ceramic skull plates are entirely artificial, but “are characterized by an excellent biocompatibility and biostability resulting in bony fusion”, because they’re made of pretty much the same molecules as the bone itself. It is important to note that the fine-grained structure of these ceramic plates is entirely different than that of true bone, but they still are completely biocompatible. This indicates the (possibly obvious) fact that chemical composition for these implants is the crucial aspect for biocompatibility, not physical structure.
Present-day neurosurgery is at a primitive stage, so the risk of paralysis, brain damage, infection, psychosis, or death is ever-present. Looking around, it seems like the overall complication rate is between 3% and 5%, but some new techniques for minimally invasive neurosurgery have complication rates as low as 1%. This is still unacceptably high for the purposes of enhancement, but the point is that the technology is improving. Handing the surgical tasks from human to robotic hands, as is becoming the standard in surgical removal of the prostate with the Da Vinci Surgical System, will help vastly lower complication rates. While complications rates for direct surgery by human hands can only be brought so low, the use of surgical precision machines potentially offers an almost unlimited domain for improvement.
I would argue that a complication rate of 1/3000 (0.033%) ought to be considered acceptable for approval of this technology. 1/3000 is roughly the annual probability that you will suffer a traumatic brain injury if you live in the United States. So, you’d be taking roughly the same chance you otherwise would in a typical year, except a successful operation would vastly lower the probability of traumatic head injury in all subsequent years. If we have such advanced surgical technology, it would be a good bet that we’d also have the technology to entirely prevent formation of scars, though that is just speculation.
Ultimately, many individuals would want to replace their entire skull with a stronger composite material, but conventional surgery might not work in this instance. More futuristically and speculatively, we might use biocompatible microbots (not nanobots!) to incrementally drill through bone, ship out the debris, and replace it with a matrix of a stronger material. This is less crazy than it sounds, as MEMS have already been in use within the body for over a decade and the area of implantable MEMS is a huge field. Swarm and cooperative robotics are also areas that have received substantial attention over the last couple decades — these fields will merge with bioMEMS to produce useful physiological sculptors at the cell-sized scale.
I also point out this area of enhancement because it seems unequivocably beneficial — as long as the complications rate is very low, who would protest against having a better-protected cranium? You might argue that we’re hard-headed enough as it is, but in my vision of the future, we’ll take that tendency to a new level.




Thanks Michael for this article.
Indeed I was thinking about the same issue a few days ago, after watching a youtube video were a patient’s head got patched with a steel plate.
My idea was to abrade the cranial bone to only a small layer and than apply plates of biocompatible protective material on top of it, rather than replacing the cranial skull completely. The biocompatibility should be in such manner that allows the underlying bone to get incorporated into, so that a strong mechanical connection is formed.
The big advantage is that the cranial cavity remains intact, which goes together with a drastical lower risk of infection. Furthermore it avoids another technical problem – the connection of the underlying tissue to the hypothetical new bone material.
http://en.wikipedia.org/wiki/Meninges
Maybe a similar technique could be used to modify facial features, so that anybody could look much more beatiful than Mendel’s lottery wants them to be.
Yes! Let’s have more like this. Innovative thinking (whether materials, techniques, collaborative frameworks, cognitive enhancement, …) situated in the here and now.
(Post-human imaginings too can be fun, but there’s a huge *pragmatic* difference.)
Michael and Ben: Bravo, yet again! Fullerene material used in the way Ben mentions would seem the best way to go for the near future. The strength and resiliene of even just a few mm of biocompatible fullerene material would be all one would need. Protecting the entire spinal column will be a bit more involved, but even micro-robotics—much less full-blown nanobots once we have these latter—should be able to systematically encase the spinal column in a biocompatible “jacket” at well (though, as Ben might concur, this might —indeed almost surely would, at least by a mm or so—also involve ablating bone material of the spinal vertebrae a bit to accomodate the fullerene casing).
Michael, what you should follow-up *this* posting with is an article advocating the development of tissue *regeneration* technology. Spinal-cord injury folks have been working on and advocating this for years, but it needs to come further—all the way, as it were—out of the closet. We want to develop medical techniques to systematically and inexpensive induce tissue/organ(s)/limb(s) regeneration. Ultimately, we want to modify our own (*germline*, inheritable) genome with the same generic sort (notice I don’t say simply the *same*, which would be a bit oversimplified) of gene(s)-ensemble that enable other animals (e.g. some amphibians and some reptiles) to regenerate their tails and even other limbs. Now the conservative bio-ethicists will no-doubt gnash their teeth over this (but WHY??!); and probably only Greg Stock, of the (now-considered) mainstream or semi-mainstream wouldn’t blink an eye at this. But, to be blunt, gnashing one’s teeth over *this* sort of (relatively innocuous) straightforwardly practical and reasonable genetic modification of standard-issue homo sap. is just STUPID. There’s virtually NO downside to what I’m advocating and a rather obvious upside. Besides, rengeneration tech R&D partially interfaces with SENS R&D, and that could be only to the good, synergetically-progressively-speaking. So—is it just me, or isn’t it almost axiomatically obvious that to pooh-pooh this sort of R&D agenda is to be a Dodo?
Anyway, great, timely article, Michael; and THANKS, Ben for your input…
Ciao…
Nice article, but you made one minor error concerning the risks.
You apparently base your estimation of the acceptable complication rate on the risk of head injury to the entire population. A better way to do this would be to look at the risk to a sub-set of the population. The acceptable complication rate for construction workers is probably going to be a lot higher than for office workers – based on the risk of head injuries.
Also gender specific risks should be considered. Males in the 18-25 age range are apparently at higher risk of death than most population segments (based on life insurance premiums) in spite of being the most healthy. This is due to them taking risks and doing dangerous things. A medical procedure that is unreasonably risky for a 25yo (who has passed the stupid age) might be considered to be worth-while for an 18yo.
A final factor you don’t seem to have considered is the fact that some head injuries will always be fatal. So of the 50,000 deaths you might only be able to save 25,000 or less no matter what you do (a sufficiently hard impact to the head will damage other parts of the body and may cause death even if the head is protected). For the 80,000 damaging but not fatal injuries, a stronger skull will not save all of them as the brain can shake inside the skull.
Assuming that half the death-toll and half the injury toll can be removed by a stronger skull seems optimistic. But we do need a lot more research on such issues.
I am curious to learn how a stronger cranial structure would have helped Natasha Richardson.
Her brain injury, as I believe most TBI cases resulting in death are, had more to do with concussion like trauma, where the brain and dura suffered trauma without the cranial structure either breaking or deforming, resulting in a lethal subcranial contusion. The only instances, it seems,(and just FYI, I am not a doctor or expert in the field) where a physically stronger cranium would be of assistance are accidents in which the cranial structure itself is damaged… which I think is a much smaller percentage of TBI related deaths. Whatever the relative percentages are between TBIs in which a cranium is broken and ones in which it is not, the risk factor for undergoing the surgery should only reflect the percentage of TBI in which the cranial structure was damaged.
Furthermore, if the flexibility of the cranium were lost in favor of hardness, that may actually cause greater damage in TBI’s where the cranial structure was not damaged. The skull having ‘give’ might be an asset in reducing trauma.
I agress with you complete Daniel.
Michael, I think you are missing a very important point. The problem is not making the skull stronger. If that were the case, I would not need to wear a padded helmet when I ride a motorcycle. A steel bucket would be sufficient.
The problem is providing enough room for the brain to slow down within the limited confines of the skull when it is subjected to an impulse. We are going to either have to become bubble heads or replace the wetware with something more durable.
Then we just make fake skulls that have more give. That could easily be done with fullerenes. Just pack them in at a lower density. That’s why I said “matrix” rather than “solid fullerene”.
If I have a skull with more give and I accidentally hit my head on a door frame, then I still get brain damage because the door pushed my softer skull into my brain.
Within the limits of materials and typical environment, I think evolution has probably optimized brain protection as much as is practical. If we want something more, there will have to be a complete redesign.
Let’s assume for the sake of discussion that minor tweaks to improve brain performance will be possible in the not too distant future.
It seems likely that delivering the performance typical of a current brain while occupying significantly less space will be easier than delivering a significant amount of extra performance. There is currently a significant range in brain sizes between people of apparently identical capacity, so engineering people to have what we consider to be above average intelligence with a below average brain size should be possible.
Given that, we would have a choice between engineering people with small heads or some padding to use the excess space.
As has been pointed out already even if we had skulls of adamantite there would still be the problem of inertia. Short of become bubble heads are there any solutions to the problem of brain inertia within the cranium?
>Dom: are there any solutions to the problem of brain inertia within the cranium?
Maybe some kind of 3D web or grid of bones inside brain what maximize the area of brain-skull contact. it can lower damage by dividing it to bigger area.
The male Bighorn sheep apparently has air sacs in it’s head to cushion it’s brain. Something similar could be done in an engineered human brain.
It wouldn’t entirely solve problems of impacts at car-crash speeds, but in conjunction with air-bags etc might do some good.
Stopping at the skull is not enough. Michael has pointed out before that the spine is pretty flimsy. Additionally, the neck is too underprotected despite being the highway for blood and oxygen. In effect I think some sort of armor that is inserted under the skin is best. Something akin to mail or scale with both strenght and flexibility. Aside from surgical complications the big problem is the rejection the body may have. I don’t really know the numbers off hand but breast implants and persons with metal in their body have been known to develop allergic reactions and ongoing health problems. Hopefully, it’s a matter of finding the right material to use that harmonizes with the body’s biochemistry. I’ve also read that inserting foreign objects into the skull (even surgical) can lead to problems with brain functioning due to interference with the body’s/brains electromagnetic field. The sooner this stuff is overcome the better. Until then I guess the only hope is a helmet/mask and a full body protective suit.
I’m glad that the key issue of brain inertia within the cranium has been raised since bruising, swelling and the increased intracranial pressure from bleeding are more often the results of head trauma that lead to death and disability. Anyone who has dropped a container of jello knows the bowl seldom breaks but the vibrations will cause the jello to literally tear itself apart. Since a very thin layer of Fullerene material would be as strong as a few millimeters of bone, it may be best to have a double-layer of fullerene plates with a shock absorber in-between, or multiple crumple layers like they have in the impact zones of newer cars. Different layers for specific protection could be included, an aerogel layer for thermal insulation, in case of fire, a graphene layer attached to ground to protect the brain from electric shocks ect. For a more extensive amount of shock protection a fullerene layer could be incorporated into the numerous folds of the brain and anchored to the inner layer of the new skull to more effectively transfer and absorb the energy of the impact. Finally, it would be wise to include a fluid drainage system with the fullerene layer along the folds of the brain so that any excess pressure can be released in the event of an unavoidable trauma. If designed right this microfluidic system could also be used to administer drugs or microrobots to specific areas in real-time.
A layer of shock-absorbers should in principle be designable even with just micro-tech. Depending on the direction of nanotech–whether wet, then keratin-hard, or, as could happen, a combination of both developmentally, over the next, say, 10-12 years, could also allow for the engineering of shock absorbers for the brain. It’s certainly true that cranial fracture is not the only or even primary cause of brain-injury-caused death.
Interesting. I wonder if evolution will take care of this in time? Those are some eye opening stats considering they are for the US only!
Re: MCP2012 & regeneration via germ line genetic modification
Be careful of unintended consequences. The cool thing about scarring is that it results from rapid clotting and prevention of massive blood loss from a traumatic wound. This is a good thing and has been a competitive advantage in our evolutionary history.
Regeneration is a tool you would like under controlled hospital situations. There are a lot more large animals that don’t regenerate than do. Now if you can get the body to undo the scarring and regenerate a limb, etc on its own “naturally” that would be cool. OR if you could find an alternate to blood clotting and scarring to prevent massive blood loss immediately following injury(on the path toward regeneration)
I want “regeneration on command”.
I like the air sacs from the Big Horn sheep analogy coupled with the stronger fullerene matrix.
What would it mean if your hair was fullerene as well, but with force feedback sensitivity. At impact it stiffens (perhaps even meshes) similar to a bulletproof vest. Not a lot of cushion, but protecting the soft wetware is likely a game of millimeters for most impacts outside projectiles, car accidents and a major fall from height.
This post made me ask what other protective bumps would impact survivability?
H+ “small” steps:
1) skull improvement to protect shock & trauma to the brain.
2) oxygen-carbon dioxide transfer in the event of heart stoppage or stroke. Micro/nano compressed oxygen artificial blood cell. Lungs are either not accessible or not functioning when this is needed. Has it’s own motive ability. (Or you could simply be diving and your lungs just don’t have any oxygen available.)
3) Micro/nano artificial “garbage cell”. Would need to be able to take away the garbage from the cell and probably store it until blood flow resumed as the liver and kidneys would probably not be functioning properly when this is needed. Has own motive ability.
4) Regeneration on command – see prior posts
5) Several pieces in process with respect to increased muscle, bone and tendon strengths & performance. I haven’t read, seen or heard anything regarding increased performance of the peripheral nervous system. I’m not sure if the increased performance of the other pieces outpaces the nervous system or not? Probably not since this is 3X-10X improvement, but it begs the question.
6) Thermal management, both dealing with over heating and hypothermia. There are devices external to the body that allow the body to cope with extreme temps in both directions. Dumping heat into the environment (or converting it to electricity to a “battery”) and creating heat. The back of your hand, tops of your feet, etc. where there are blood vessels close to the skin are primary targets for thermal management systems. I can’t think of anything organic or readily applicable and unobtrusive that could be “built in.”
Others include:
1)Built in computer and communication system.
2)Improved vision across spectrum and adjustable focal lengths. (Other senses too of course.)
3)Impregnating the skin with metals or other high strength bio-compatible nano-agents to increase durability, strength and flexibility of the epidermis. This is happening with organics today, but more readily targeting tendons and cartilage.
Sorry to go “off topic” a bit.