See here.

I generally disagree with George here. We can defeat aging, run cars on renewable fuels, address climate change, and develop a sustainable energy source without a fundamental breakthrough like quantum mechanics. It could be the end of scientific revolutions as we know them — it’s hard to tell. We could still have extreme (incremental) progress in science without discrete, paradigm-shifting revolutions.

I really need to read John Horgan’s book, The End of Science. Even though I found him rude in our exchange, I have sympathy for some of his ideas, like the notion that war might be eliminated or that fundamental scientific revolutions may be over.

At the very least, it could be that human-facilitated paradigm shifts are over, and that superintelligence is necessary to tear further holes in the fabric of the Veil of Maya.

But ultimately…

“Nobody actually lives in external reality, and we couldn’t understand it if we did; too many quarks flying around.” — Eliezer Yudkowsky