// Working Towards Apotheosis
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    The Singularity Institute for Artificial Intelligence (SIAI) is a nonprofit corporation dedicated solely to the technological creation of real AI. Unencumbered by the incrementalist approach to AI of most business and academia, SIAI is devoted to furthering both discussion and research in AI and the domain knowledge required to implement it. Operating since 2000.

           
    From their site: "Advanced nanotechnology can build machines that are thousands of times more powerful—and hundreds of times cheaper—than today's devices. The humanitarian potential is enormous; so is the potential for misuse. The vision of CRN is a world in which nanotechnology is widely used for productive and beneficial purposes, and where malicious uses are limited by effective administration of the technology."
    The Lifeboat Foundation is the world's only comprehensive effort to mitigate existential risk, that is, potential disasters which could wipe out all of humanity. Up until recently, the only main existential risk was nuclear war, but others are emerging. Lifeboat is dedicated to confronting them.
    Another, newer transhumanist organization. Differs in flavor from ExI, although there is significant membership overlap. Also worth checking out if you care about transhumanism. With chapters all over the world, WTA's purpose is to serve as an umbrella organization for transhumanists. The WTA also holds an annual conference in a different spot each year.
    ImmInst is another umbrella organization - the first of its kind - created to help its members succeed in working towards the possibility of radical life extension and potentially indefinite lifespans. Methods discussed include germline therapy, medical nanotechnology, cryonics, and others. ImmInst recently had its first conference in November 2005, has released a book, and will be releasing a documentary shortly.  
                 
    "ASF explores the accelerating development of special domains in science and technology, and examines their impact on business and society. In particular, we consider longstanding accelerating scientific and technological trends in computation, communication, storage, digitization, simulation, sensing, energy density, energy efficiency, miniaturization, autonomy, and others, and the way these developmental trends interact with business and social agendas. We seek to use this knowledge in service of greater personal, executive, and professional development."